Sophia plays Detective Erin Lindsay.
Sophia was married to her One Tree Hill co-star Chad Michael Murray from 2005-2006, before getting divorced. She later stated, about the relationship: "We were two stupid kids who had no business being in a relationship in the first place."
Bush has also dated One Tree Hill co-stars James Lafferty & Austin Nichols, and Dan Fridinburg, a program manager for Google.
Sophia's 9-year-old second cousin, Christina-Taylor Green, was fatally shot in the assassination attempt on Rep. Gabrielle Giffords in Tucson, Arizona. Green was the youngest victim of the massacre, which killed six people.
Bush also uses her social media platforms (Twitter, Instagram, Facebook) and her blog to raise awareness of world events and fundraisers in which she takes part. Bush is a part of fundraisers such as Fuck Cancer, Run For the Gulf, and Global Green Gulf Relief.